Hou et al (2005) researched the autonomic outcomes of modafinil in humans. They found that modafinil has an effect on the locus coeruleus, which mediates pupil diameter and arousal, but it does not have an affect on other autonomic features, which are controlled by noreadrenergic Regulate centers (A1 – A5) located beyond the locus coeruleus.cyclo
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